Hope E. Merens

This study shows SRSF1 regulates 3'-end site selection through mechanisms both independent and dependent on U1 snRNP, affecting RNA isoform determination in breast cancer.

The paper identifies genes involved in mitochondrial and nuclear gene regulation for OXPHOS complex synthesis using genome-wide screens and characterizes their roles in mitochondrial RNA abundance and mitoribosome assembly.

This study shows that SUPT5H mutations disrupt RNA polymerase II pausing, delaying erythroid differentiation and cell cycle progression in human cells.