Ana Fiszbein

SpliceImpactR identifies and predicts the impact of alternative RNA processing events on protein function across the human transcriptome, revealing widespread context-dependent effects on the proteome.

This study shows SRSF1 regulates 3'-end site selection through mechanisms both independent and dependent on U1 snRNP, affecting RNA isoform determination in breast cancer.

The paper shows that inhibiting the CoREST complex with corin alters RNA splicing, increases neoantigen expression, and enhances tumor immunity in melanoma.

The paper shows that an antisense oligonucleotide promotes gene looping and long-distance promoter activation through chromatin conformation changes.

The paper identifies a spatial coordination between mRNA initiation and termination sites, proposing a 'Positional Initiation-Termination Axis' that influences isoform diversity.

Biosurfer identifies sources of protein isoform diversity by analyzing long-read RNA-seq data, revealing common mechanisms like alternative transcription start sites and 'ragged codons'.

This study constructs a large-scale cancer-specific TF-DNA interaction network and identifies potential therapeutic targets among oncogenes and TFs.

evopython provides a Python package for sequence-aware genomic coordinate resolution using alignment data, improving upon coordinate-centric tools like LiftOver.

The paper identifies EMATS genes and demonstrates their therapeutic potential by using small molecules and ASOs to enhance gene expression through splicing-dependent transcriptional activation.

The paper identifies hybrid internal-terminal exons in human transcriptomes using a new pipeline and shows their tissue-specific usage and association with RNA splicing genes.

The paper identifies exon-mediated activation of transcription starts (EMATS) as a mechanism where splicing of internal exons influences promoter usage and gene expression in mammals.