Author

Chia-Ni Tsai

École Polytechnique Fédérale de LausanneORCID 0000-0002-2008-3400Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Assay:multiome· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandre PersatiD· 2 shared Zainebe Al‐Mayyah· 2 shared Aaron WeimanniD· 1 shared Fouad Mohamed Fouad Elgebely· 1 shared Laure Le BlanciD· 1 shared Lucas Andrade MeirellesiD· 1 shared Michaël NilgesiD· 1 shared R. Andrés FlotoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

Alexandre PersatORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A structural trade-off balances mechanical resilience and supramolecular adaptability in type IV pili

Chia-Ni Tsai, Laure Le Blanc, Fouad Mohamed Fouad Elgebely, Zainebe Al‐Mayyah, Michaël Nilges, Alexandre Persat, Yasaman Karami

This study identifies a structural trade-off in type IV pili that balances mechanical resilience and supramolecular adaptability using cryo-EM, simulations, and experimental validation.

bioRxiv · Jul 4, 2026 · PreprintBiophysics

Pseudomonas aeruginosa balances cytotoxicity and motility to counter phagocytosis by macrophages

Tania Distler, Chia-Ni Tsai, Aaron Weimann, Zainebe Al‐Mayyah, Lucas Andrade Meirelles, R. Andrés Floto, Alexandre Persat

This study shows that Pseudomonas aeruginosa uses motility to enhance phagocytosis by macrophages, while reduced motility in chronic infections helps evade engulfment, and T3SS activity enables acute immune evasion.

bioRxiv · Apr 3, 2026 · PreprintMicrobiology