Alexandre Persat

This study identifies dalberoside, a glycolipid that inhibits bacterial surface attachment and biofilm formation by remodeling the outer membrane interface without killing bacteria.

This study identifies a structural trade-off in type IV pili that balances mechanical resilience and supramolecular adaptability using cryo-EM, simulations, and experimental validation.

This study shows that pyocyanin disrupts airway epithelial regeneration, alters tissue architecture, and promotes chronic Pseudomonas aeruginosa infection.

This study shows that Pseudomonas aeruginosa becomes more tolerant to antibiotics when grown in confined spaces, due to mechanical stress-induced changes in efflux and membrane remodeling.

This study shows that Pseudomonas aeruginosa uses motility to enhance phagocytosis by macrophages, while reduced motility in chronic infections helps evade engulfment, and T3SS activity enables acute immune evasion.

This study uses human colonic organoids to reveal how Enterococcus faecalis adapts to intestinal mucus, identifying key fitness determinants and colonization strategies not observed in vitro or in vivo.

This study investigates how Pseudomonas aeruginosa adapts to the airway environment by balancing biofilm formation for colonization and antibiotic tolerance, revealing trade-offs that contribute to chronic infections.

This study identifies a spatial mechanism of sensory adaptation in Pseudomonas aeruginosa, revealing how enzyme localization modulates mechanosensing and virulence.