The paper introduces Rubik, a fluorescent reporter that tracks Cre and Flp recombination sequences and enables optogenetic control through temporal recombination events.

bioRxiv · Nov 20, 2024 · PreprintMolecular Biology

Multiscale networks in multiple sclerosis

Keith Kennedy, Nicole Kerlero de Rosbo, Antonio Uccelli, Maria Cellerino, Federico Ivaldi, Paola Contini, Raffaele De Palma, Hanne Flinstad Harbo, Tone Berge, Steffan D. Bos, Einar August Høgestøl, Synne Brune, Sigrid A. de Rodez Benavent, Friedemann Paul, Alexander Ulrich Brandt, , Pablo Villoslada

The paper uses multilayer network analysis and multi-omics data to identify biological pathways in MS that explain disease severity and central nervous system damage.

PLoS Computational Biology · Feb 8, 2024Peer-reviewedSystems Biology

Enrichment analysis of GWAS data in autoimmunity delineates the multiple sclerosis-Epstein Barr virus association

Rosella Mechelli, Renato Umeton, Virginia Rinaldi, Gianmarco Bellucci, Rachele Bigi, Daniela Francesca Angelini, Gisella Guerrera, Sundararajan Srinivasan, Silvia Romano, Maria Chiara Buscarinu, Raffaella Pizzolato Umeton, Eleni Anastasiadou, Pankaj Trivedi, Arianna Fornasiero, Michela Ferraldeschi, , Giovanni Ristori

This study identifies a link between Epstein Barr virus and multiple sclerosis through enrichment analysis of GWAS data and biological validation.

bioRxiv · Jun 6, 2021 · PreprintNeuroscience