Sundararajan Srinivasan

Genome-wide association study of varenicline-aided smoking cessation

This paper conducts a genome-wide association study to identify genetic variants associated with varenicline-aided smoking cessation using electronic health records.

Genome-wide association analysis reveals insights into the molecular aetiology underlying dilated cardiomyopathy

This study identifies 80 genetic loci and 61 effector genes associated with dilated cardiomyopathy through GWAS and integrates transcriptomic data to uncover biological pathways and cellular states involved in the disease.

Multi-ancestry genome-wide association study of neutrophil-lymphocyte ratio and polygenic risk score development to explore causal association with diabetic retinopathy

This paper conducts a multi-ancestry GWAS to identify genetic loci influencing NLR and develops a PRS to assess its causal association with DR, finding no significant causal link.

Genome-wide association study of placental weight in 179,025 children and parents reveals distinct and shared genetic influences between placental and fetal growth

This study identifies 40 genetic loci associated with placental weight using GWAS in 179,025 children and parents, revealing shared and distinct genetic influences with fetal growth.

Common and distinct genetic architecture of age at diagnosis of diabetes in South Indian and European populations

This study identifies genetic loci associated with age at diagnosis of T2D in South Indian and European populations, revealing shared and distinct genetic architectures.

XBP1 expression in pancreatic islet cells is associated with poor glycaemic control across ancestries especially in young non-obese onset diabetes

This study identifies XBP1 expression in pancreatic islets as a genetic factor associated with poor glycaemic control and increased T2DM risk in South and East Asians, particularly in young non-obese onset diabetes.

Common and rare variants in SLCO1B1 are associated with statin intolerance

This study shows that considering both loss-of-function and gain-of-function variants in SLCO1B1 improves the prediction of statin intolerance compared to using only the Val174Ala variant.

LTA4H association with montelukast response in early and late-onset asthma

This study investigates the association between LTA4H genetic variant rs2660845 and montelukast response in early-onset asthma, finding increased exacerbation risk in European carriers.

Enrichment analysis of GWAS data in autoimmunity delineates the multiple sclerosis-Epstein Barr virus association

This study identifies a link between Epstein Barr virus and multiple sclerosis through enrichment analysis of GWAS data and biological validation.

Significant enrichment of Herpesvirus interactors in GWAS data suggests causal inferences for the association between Epstein Barr virus and multiple sclerosis

The paper identifies significant enrichment of Herpesvirus interactors in GWAS data, suggesting a causal role for Epstein-Barr virus in multiple sclerosis.