Integrated analysis of multimodal long-read epigenetic assays
Jeremy Marcus, Oberon Dixon-Luinenburg, Nathan I. Gamarra, Jacob Price Schwartz, Michal Rozenwald, Annie Maslan, Fyodor D. Urnov, Aaron F. Straight, Nicolas Altemose, Nilah M. Ioannidis, Aaron Streets
The paper introduces dimelo-toolkit, a Python package for analyzing multimodal long-read epigenetic data, demonstrating its use with a novel DiMeLo-seq protocol to study chromatin state in GM12878 cells.
bioRxiv · Nov 9, 2025 · PreprintGenomics