Jacob Price Schwartz

The paper uses a complete diploid human genome to study centromeric chromatin organization, revealing that DNA methylation regulates centromere structure and plasticity.

The paper introduces dimelo-toolkit, a Python package for analyzing multimodal long-read epigenetic data, demonstrating its use with a novel DiMeLo-seq protocol to study chromatin state in GM12878 cells.

This study identifies a cell cycle-dependent phosphorylation mechanism that regulates M18BP1 binding to CENP-A nucleosomes, controlling CENP-A assembly during interphase.

This study identifies the role of H3K9 methyltransferases in maintaining centromere compartmentalization by regulating CENP-A and heterochromatin distribution.

DiMeLo-cito improves DiMeLo-seq by eliminating wash steps, enabling mitotic protein-DNA interaction analysis in diploid human cells and revealing CTCF bookmarking.