Author

Justin L. Engel

The University of Texas Southwestern Medical CenterORCID 0000-0002-2016-3494Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Ahyeon Ko· 1 shared Alistair G. RustiD· 1 shared Amanda K. MennieiD· 1 shared Angad KumariD· 1 shared Chengheng LiaoiD· 1 shared Emilija AleksandroviciD· 1 shared Ianthe A. E. M. van BelzeniD· 1 shared Isidro Cortés‐CirianoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Ahyeon Ko

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1 paper

Recent·Most cited

A single chromosome 3p break initiates clear cell renal cell carcinoma evolution

Rashmi Dahiya, Ianthe A. E. M. van Belzen, Chengheng Liao, Angad Kumar, Yu-Fen Lin, Ahyeon Ko, Amanda K. Mennie, Emilija Aleksandrovic, Jin Zhou, Qing Hu, Justin L. Engel, Jeffrey Miyata, Jose Espejo Valle-Inclán, Alistair G. Rust, Ravikanth Maddipati, , Peter Ly

This study shows that a single chromosome 3p break initiates ccRCC evolution by creating a fitness bottleneck that selects for recurrent aneuploidies.

bioRxiv · Jul 10, 2026 · PreprintCancer Biology