Emilija Aleksandrovic

The paper maps gene-by-gene-by-environment epistasis in cancer metastasis using CRISPR perturbations in mice, showing niche-dependent fitness and transcriptome convergence.

This study identifies tumor-intrinsic IFNγ signaling and niche adaptation as key drivers of early colonization in ovarian cancer metastasis using MetTag, a single-cell barcoding approach.

This study shows that a single chromosome 3p break initiates ccRCC evolution by creating a fitness bottleneck that selects for recurrent aneuploidies.

This study uses a hybrid in vivo model to show that the aged extracellular matrix promotes breast cancer progression, with LOX identified as a key driver.