Author

Rashmi Dahiya

Children's Medical CenterORCID 0000-0002-7985-0862Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Peter LyiD· 2 shared Ahyeon Ko· 1 shared Alison HarrodiD· 1 shared Alistair G. RustiD· 1 shared Amanda K. MennieiD· 1 shared Angad KumariD· 1 shared Anne-Laure CattiniD· 1 shared Annika FendleriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Peter LyORCID

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2 papers

Recent·Most cited

A single chromosome 3p break initiates clear cell renal cell carcinoma evolution

Rashmi Dahiya, Ianthe A. E. M. van Belzen, Chengheng Liao, Angad Kumar, Yu-Fen Lin, Ahyeon Ko, Amanda K. Mennie, Emilija Aleksandrovic, Jin Zhou, Qing Hu, Justin L. Engel, Jeffrey Miyata, Jose Espejo Valle-Inclán, Alistair G. Rust, Ravikanth Maddipati, , Peter Ly

This study shows that a single chromosome 3p break initiates ccRCC evolution by creating a fitness bottleneck that selects for recurrent aneuploidies.

bioRxiv · Jul 10, 2026 · PreprintCancer Biology

Genome-wide Chromosome-specific Aneuploidy Engineering and Phenotypic Characterization with CRISPR-Taiji

Hugang Feng, Daqi Deng, Rashmi Dahiya, Libin Wang, Jingkun Zeng, Benjy J.Y. Tan, Fiona Byrne, Scott T.C. Shepherd, Jiahao Wang, Sarah C. Johnson, Alison Harrod, Karen A. Lane, Annika Fendler, Anne-Laure Cattin, Zayd Tippu, , Samra Turajlic

The paper introduces CRISPR-Taiji to engineer chromosome-specific aneuploidy and characterizes its transcriptomic effects, linking aneuploidy to ccRCC phenotypes.

bioRxiv · Apr 25, 2025 · PreprintGenomics