Precise amplification-free detection of highly structured RNA with an enhanced SCas12a assay
Junqi Zhang, Wenhao Yin, Qingyuan Jiang, Wuxiang Mao, Wenwen Deng, Shuqi Jin, Xinping Wang, Ruyi He, Jie Qiao, Yi Liu
This paper introduces an enhanced SCas12a assay (SCas12aV2) for amplification-free detection of highly structured RNA, showing improved sensitivity and specificity for RNA and clinical samples.
Communications Biology · Mar 4, 2025Peer-reviewedMolecular Biology