Author

Andrew D. Mitchell

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteORCID 0000-0002-2018-4359Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Hanfeng LiniD· 1 shared Jennifer Ann WoyachiD· 1 shared Jin WangiD· 1 shared Qi XL· 1 shared Ran ChengiD· 1 shared Shrilekha MisraiD· 1 shared Xin Yu· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Hanfeng LinORCID

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1 paper

Recent·Most cited

Sub-stoichiometric Degradation is Dispensable for Potent PROTACs: A Case Study for Irreversible Covalent BTK Degraders

Ran Cheng, Hanfeng Lin, Xin Yu, Shrilekha Misra, Andrew D. Mitchell, Jennifer Ann Woyach, Qi XL, Jin Wang

This paper develops and characterizes PSIRC3, a covalent PROTAC for BTK, showing it achieves potent degradation with sub-nanomolar potency and high selectivity, challenging the necessity of catalytic turnover for PROTAC efficacy.

bioRxiv · Feb 15, 2026 · PreprintBiochemistry