Jennifer Ann Woyach

Sub-stoichiometric Degradation is Dispensable for Potent PROTACs: A Case Study for Irreversible Covalent BTK Degraders

This paper develops and characterizes PSIRC3, a covalent PROTAC for BTK, showing it achieves potent degradation with sub-nanomolar potency and high selectivity, challenging the necessity of catalytic turnover for PROTAC efficacy.

Long-read single-cell RNA sequencing enables the study of cancer subclone-specific genotype and phenotype in chronic lymphocytic leukemia

This study uses long-read scRNA-seq to analyze cancer subclone-specific mutations and transcriptomic differences in CLL patients with BTKC481S mutations.

Characterization and Mitigation of Fragmentation Enzyme-Induced Dual Stranded Artifacts

This paper identifies and mitigates sequencing artifacts caused by fragmentation enzymes, presenting FADE software to remove these artifacts and reduce their impact on downstream analyses.