Xin Yu

A feed-forward loop between niche adenosine and Gzmk⁺ CD8 T cells propagates systemic inflammaging

This study identifies an adenosine-Gzmk axis that drives T cell aging and systemic inflammaging, showing that targeting it can reverse aging phenotypes and extend lifespan in mice.

Sub-stoichiometric Degradation is Dispensable for Potent PROTACs: A Case Study for Irreversible Covalent BTK Degraders

This paper develops and characterizes PSIRC3, a covalent PROTAC for BTK, showing it achieves potent degradation with sub-nanomolar potency and high selectivity, challenging the necessity of catalytic turnover for PROTAC efficacy.

A mediterranean-mimicking diet harnesses gut microbiota-derived 3-IAA to rejuvenate T cell

This study shows a Mediterranean diet enhances antitumor immunity via gut microbiota-derived 3-IAA, which boosts T cell function and synergizes with immunotherapy.

Blind Virtual Screening at Scale: A Scalable End-to-End Pipeline for Blind Docking and Affinity Prediction

This paper presents a scalable end-to-end pipeline for blind virtual screening using DiffDock and UniDock Vina, achieving high screening performance with minimal pose generation.

One Tracer, Dual Platforms: Unlocking Versatility of Fluorescent Probes in TR-FRET and NanoBRET Target Engagement Assays

This paper evaluates two fluorescent tracers for use in TR-FRET and NanoBRET assays, showing they can be used across platforms with consistent performance.

Chemical Induction of Longevity-Promoting Colanic Acid in the Host's Microbiota

This study shows that low-dose cephaloridine induces colanic acid production in gut bacteria, extending host lifespan in C. elegans and mice.

Comparative genetic architectures of schizophrenia in East Asian and European populations

This study identifies schizophrenia genetic associations in East Asian and European populations, finding similar genetic effects across ancestries but highlighting challenges in polygenic risk prediction across groups.

Low nutrient levels reduce the fitness cost of MexCD-OprJ efflux pump overexpression in ciprofloxacin-resistant Pseudomonas aeruginosa

This study shows that low nutrient levels reduce the fitness cost of ciprofloxacin resistance in Pseudomonas aeruginosa due to decreased efflux pump expression and altered gene regulation.