Pharmacology & ToxicologyNature CommunicationsPeer-reviewed
MRAP2 modifies signaling and oligomerization state of the melanocortin-4 receptor
Iqra Sohail, Suli‐Anne Laurin, Gunnar Kleinau…·Heike Biebermann
This study shows that MRAP2 modifies MC4R signaling and oligomerization, enhancing G protein signaling while reducing beta-arrestin2 recruitment and receptor internalization.