Author

Nicholas Spellmon

Howard Hughes Medical InstituteORCID 0000-0002-2045-1373Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein structure prediction· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Adamo S. MancinoiD· 2 shared Boris RudolfsiD· 2 shared Daniel B. HaackiD· 2 shared Jason HingeyiD· 2 shared Navtej TooriD· 2 shared Rhiju DasiD· 2 shared Yuan WuiD· 2 shared Zhiheng YuiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Adamo S. MancinoORCID

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2 papers

Recent·Most cited

De novo design of RNA pseudoknots with deep learning

Jill Townley, Wipapat Kladwang, David A. Baker, Hamish M. Blair, Christian A. Choe, Gina El Nesr, Andrew Favor, Eli Fisker, Daniel B. Haack, Shujun He, Jason Hingey, Po‐Ssu Huang, Chaitanya K. Joshi, Thomas Karagianes, Andrew Kubaney, , Rhiju Das

This paper demonstrates that deep learning can accurately design RNA pseudoknots, achieving results comparable to human experts in a competition.

Science · Aug 27, 2026Peer-reviewedBiophysics

Cryo-EM of a nucleotide-polymerizing ribozyme enables its predictive improvement

Deni Szokoli, Jason Hingey, Yuan Wu, Daniel B. Haack, Nicholas Spellmon, Boris Rudolfs, Adamo S. Mancino, Zhiheng Yu, Navtej Toor, Rhiju Das

The paper uses cryo-EM to study a ribozyme's structure, revealing how it evolved to polymerize nucleotides and how mutations can enhance its function.

bioRxiv · Aug 19, 2026 · PreprintBiochemistry