Zhiheng Yu

This paper demonstrates that deep learning can accurately design RNA pseudoknots, achieving results comparable to human experts in a competition.

The paper uses cryo-EM to study a ribozyme's structure, revealing how it evolved to polymerize nucleotides and how mutations can enhance its function.

The paper identifies RBMP2 as essential for forming the reticulated membrane region in the algal pyrenoid, which is critical for CO2 delivery and growth.

The paper identifies components of mammalian sperm nuclear vacuoles using cryo-ET and AlphaFold docking, revealing proteasomes, PA200, and ferritin, and their structural roles.

The paper uses time-resolved cryo-EM to show how acetyl-CoA binding induces conformational changes in ICL2, leading to asymmetric catalytic activity.

The paper determines the Cryo-EM structure of Cfr, revealing its mechanism of C8 methylation on 23S rRNA and its role in antibiotic resistance.

The paper investigates the structure of chromatin condensates across scales and shows how nucleosome arrangement and histone interactions influence their physical properties.

The paper develops methods to analyze chromatin condensates using cryo-electron tomography and deep learning, revealing nucleosome structures and interactions in both reconstituted and native systems.

The paper releases high-resolution 3D imaging and nucleus segmentations of seven tissues from a P7 mouse using FIB-SEM and machine learning.

This study reveals the architecture and flexibility of native kinetochores using structural analyses of purified kinetochores from thermophilic yeast.

The paper develops methods to image glutamatergic synapses in hippocampal tissue using cryo-electron tomography, enabling high-resolution visualization of synaptic structures.

The paper shows a D-peptide disassembles AD-tau fibrils via a strain-relief mechanism involving oppositely twisted fibrils.

This paper reports the structure of Arabidopsis RDR2 and shows how it initiates transcription from RNA templates displaced from RNA-DNA hybrids.

This study identifies the structural basis of Rubisco phase separation in the pyrenoid by analyzing interactions between Rubisco and its linker protein EPYC1 in Chlamydomonas reinhardtii.