Graham L Radford‐Smith

Resolving inflammatory bowel disease risk variants to genes and cell types

This study identifies 619 IBD risk signals, resolves 81 high-confidence variants, and prioritizes 664 candidate effector genes using GWAS, eQTL, and exome sequencing.

Brain signatures of chronic gut inflammation

This study examines how chronic gut inflammation in IBD affects brain dynamics using EEG, finding altered brain states and connectivity patterns in CD and UC patients.

An extremes of phenotype approach confirms significant genetic heterogeneity in patients with ulcerative colitis.

This study identifies genetic heterogeneity in ulcerative colitis by analyzing genome-wide associations in mild and severe cases, finding distinct risk variants and a genetic risk score with no difference between mild and severe disease.

Microbiota links to neural dynamics supporting threat processing

This study investigates how gut microbiota influences neural dynamics in threat processing by combining neuroimaging, 16S rRNA profiling, and computational modeling in healthy participants.

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

This paper identifies novel pleiotropic risk loci for melanoma and nevus density, implicating multiple biological pathways and gene expression under MITF regulation.