An extremes of phenotype approach confirms significant genetic heterogeneity in patients with ulcerative colitis.
Sally Mortlock, Anton Lord, Grant W. Montgomery, Martha Zakrzewski, Lisa A. Simms, Krupa Krishnaprasad, Katherine Hanigan, James D. Doecke, Alissa J. Walsh, Ian Craig Lawrance, Peter A. Bampton, Jane Mary Andrews, Gillian Mahy, Susan Jane Connor, Miles Sparrow, , Graham L Radford‐Smith
This study identifies genetic heterogeneity in ulcerative colitis by analyzing genome-wide associations in mild and severe cases, finding distinct risk variants and a genetic risk score with no difference between mild and severe disease.
Journal of Crohn s and Colitis · Sep 14, 2022Peer-reviewedGenetics