Fan Liu

The paper presents a pipeline for analyzing image-based complex traits using AI phenotyping, combined-GWAS, and federated learning, applied to human facial data to identify genetic loci associated with facial shape.

This paper evaluates polygenic and methylation risk scores for predicting overweight-related hypertension in Chinese populations, finding improved accuracy with integrated multi-omics approaches.

This paper introduces encG-reg, an encrypted genotype regression method that identifies relatives across cohorts without sharing raw data, achieving accuracy comparable to traditional methods.

FastQTLmapping is a C++ package that performs mQTL analysis and large-scale linear regressions efficiently, outperforming MatrixEQTL in speed and memory usage.

This paper shows that knocking out TBX15 and PAX1 in mice alters facial and physical morphology, supporting their role in human facial development.

The paper demonstrates that the XIST RNA-protein complex has a modular architecture that determines RBP binding and m6A modification, beyond sequence motifs.

This study identifies 24 genetic loci associated with facial shape variation in humans through GWAS and confirms 13 of them in a multi-ethnic cohort.

This paper identifies novel pleiotropic risk loci for melanoma and nevus density, implicating multiple biological pathways and gene expression under MITF regulation.