Author

Xiaoru Chen

Jewish General HospitalORCID 0000-0002-2051-889XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Abhishek BastirayiD· 1 shared Alexandre MaréchaliD· 1 shared Alexandre OrthweiniD· 1 shared Benjamin LebeauiD· 1 shared Billel Djerir· 1 shared Damien Grapton· 1 shared Edgar Pinedo CarpioiD· 1 shared Estelle R. Simo‐Cheyou· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

Abhishek BastirayORCID

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2 papers

Recent·Most cited

BiophysicsScience AdvancesPeer-reviewedJul 31, 2026

Molecular mechanism by which SARS-CoV-2 Orf9b suppresses the Tom70-Hsp90 interaction to evade innate immunity

Noah Sherer, Abhishek Bastiray, Xiaoru Chen…·Jaehyun Cho

This study identifies how SARS-CoV-2 Orf9b inhibits the Tom70-Hsp90 interaction to suppress IFN production using structural and thermodynamic analyses.

4 citationstop 2%

experimental assayhost-pathogen & immune response

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Molecular BiologybioRxivPreprintJun 28, 2021

POGZ modulates the DNA damage response in a HP1-dependent manner

John Heath, Estelle R. Simo‐Cheyou, Steven Findlay…·Alexandre Orthwein

This study identifies POGZ as a regulator of HP1-dependent DNA repair, showing its role in homology-directed repair and its clinical relevance to White Sutton syndrome.

DOI 10.1101/2021.06.28.447216

mouseDNA methylation

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