ImmunologybioRxivPreprint
Weak SLP-76-PLC-γ1 interaction in the LAT-nucleated multi-protein complex fine-tunes TCR signal strength to optimize T cell responsiveness
Hidehiro Yamane, Junya Wada, Elizabeth N. Stassenko…·Lawrence E. Samelson
The paper shows that a weak SLP-76-PLC-γ1 interaction fine-tunes TCR signal strength, optimizing T cell responsiveness by controlling PLC-γ1 activity.
DOI 10.1101/2025.09.11.675682