Author

Lawrence E. Samelson

National Institutes of HealthORCID 0000-0002-5963-2112Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alison Ma· 1 shared Andy D. TraniD· 1 shared Dorian B. McGaverniD· 1 shared Elizabeth N. Stassenko· 1 shared Herbert Hagenau· 1 shared Hidehiro YamaneiD· 1 shared Jason YiiD· 1 shared Joseph A. GarveyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

Alison Ma

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 11, 2025

Weak SLP-76-PLC-γ1 interaction in the LAT-nucleated multi-protein complex fine-tunes TCR signal strength to optimize T cell responsiveness

Hidehiro Yamane, Junya Wada, Elizabeth N. Stassenko…·Lawrence E. Samelson

The paper shows that a weak SLP-76-PLC-γ1 interaction fine-tunes TCR signal strength, optimizing T cell responsiveness by controlling PLC-γ1 activity.

DOI 10.1101/2025.09.11.675682

mouseproteomics

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ImmunologyFrontiers in ImmunologyPeer-reviewedDec 24, 2024

CD28 Shapes T Cell Receptor Signaling by Regulating ZAP70 Activation and Lck Dynamics

Kumarkrishna Raychaudhuri, Rohita Rangu, Alison Ma…·Lawrence E. Samelson

This study shows CD28 co-stimulation accelerates ZAP70 recruitment and activation in TCR microclusters by enhancing Lck dynamics and spatial separation of Lck species.

16 citations

humanproteomics

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