Weak SLP-76-PLC-γ1 interaction in the LAT-nucleated multi-protein complex fine-tunes TCR signal strength to optimize T cell responsiveness
Hidehiro Yamane, Junya Wada, Elizabeth N. Stassenko, Natalie D. Convertino, Mariah E. Lee, Melanie S. Vacchio, Wenmei Li, Udumbara M. Rathnayake, Lakshmi Balagopalan, Raj Chari, Herbert Hagenau, Parirokh Awasthi, Dorian B. McGavern, Rémy Bosselut, Lawrence E. Samelson
The paper shows that a weak SLP-76-PLC-γ1 interaction fine-tunes TCR signal strength, optimizing T cell responsiveness by controlling PLC-γ1 activity.
bioRxiv · Sep 11, 2025 · PreprintImmunology