Author

Junya Wada

National Institutes of HealthORCID 0009-0002-7281-5703Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Dorian B. McGaverniD· 1 shared Elizabeth N. Stassenko· 1 shared Herbert Hagenau· 1 shared Hidehiro YamaneiD· 1 shared Lakshmi BalagopalaniD· 1 shared Lawrence E. SamelsoniD· 1 shared Mariah E. LeeiD· 1 shared Melanie S. VacchioiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Dorian B. McGavernORCID

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1 paper

Recent·Most cited

Weak SLP-76-PLC-γ1 interaction in the LAT-nucleated multi-protein complex fine-tunes TCR signal strength to optimize T cell responsiveness

Hidehiro Yamane, Junya Wada, Elizabeth N. Stassenko, Natalie D. Convertino, Mariah E. Lee, Melanie S. Vacchio, Wenmei Li, Udumbara M. Rathnayake, Lakshmi Balagopalan, Raj Chari, Herbert Hagenau, Parirokh Awasthi, Dorian B. McGavern, Rémy Bosselut, Lawrence E. Samelson

The paper shows that a weak SLP-76-PLC-γ1 interaction fine-tunes TCR signal strength, optimizing T cell responsiveness by controlling PLC-γ1 activity.

bioRxiv · Sep 11, 2025 · PreprintImmunology