NeurosciencebioRxivPreprint
Transient Acute Neuronal Activation Response Caused by High Concentrations of Oligonucleotides in the Cerebral Spinal Fluid
Mariana Bravo Hernandez, Curt Mazur, Hao Chen…·Holly B. Kordasiewicz
The paper characterizes a transient neurobehavioral response to high-dose oligonucleotide delivery in the CNS and provides a framework to mitigate it through magnesium supplementation.