Author

Hans J. Gaus

Ionis Pharmaceuticals (United States)ORCID 0000-0002-7471-8619Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Organism:non-human primate· 2 Research Focus:drug response / drug discovery· 1 Organism:rat· 1

Frequent Co-Authors

Eric E. SwayzeiD· 2 shared Holly B. KordasiewicziD· 2 shared Paymaan Jafar‐NejadiD· 2 shared Alfred E. ChappelliD· 1 shared Andrew RodrigueziD· 1 shared António Pinto‐DuarteiD· 1 shared Berit E. PowersiD· 1 shared Bret Holguin· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Eric E. SwayzeORCID

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2 papers

Recent·Most cited

Delivery of small interfering RNA and antisense oligonucleotides across the blood-brain barrier with monovalent transferrin receptor 1 binding VHH-Fc fusion proteins

Ian J. Huggins, Michele Carrer, Jinro A. Santos, Michael Fazio, Bret Holguin, Stevee Phi, Thazha P. Prakash, Megan E. Afetian, Mohsen Afshar Bakooshli, Stephanie K. Klein, Rodrigo Galindo‐Murillo, Andrew Rodriguez, Fredrik Kamme, Hans J. Gaus, Alfred E. Chappell, , Eric E. Swayze

This paper develops a VHH-Fc fusion protein to deliver siRNAs and ASOs across the BBB in rodents and NHPs, showing that binding affinity, DAR, and conjugation site affect delivery efficiency.

bioRxiv · Aug 20, 2026 · PreprintNeuroscience

Transient Acute Neuronal Activation Response Caused by High Concentrations of Oligonucleotides in the Cerebral Spinal Fluid

Mariana Bravo Hernandez, Curt Mazur, Hao Chen, Linda Fradkin, Justin Searcy, Sebastien A. Burel, M Elizabeth Kelly, Dona Bruening, Jacqueline G. O’Rourke, Yuhang Cai, Jonathon Nguyen, Lisa D. Berman-Booty, Lendell L. Cummins, Hans J. Gaus, Berit E. Powers, , Holly B. Kordasiewicz

The paper characterizes a transient neurobehavioral response to high-dose oligonucleotide delivery in the CNS and provides a framework to mitigate it through magnesium supplementation.

bioRxiv · Feb 13, 2025 · PreprintNeuroscience