Onn Brandman

Transcriptional Response to Tumor Mutational Burden Is Consistent Across Cancer Types

The paper analyzes ~9,100 tumors across 32 cancer types to determine if the transcriptional response to tumor mutational burden (TMB) is consistent across tissues, finding it to be largely consistent within each cancer type.

Nup42 safeguards heat-induced mRNAs from nuclear condensation tosupport chaperone synthesis

The paper identifies Nup42 as a key factor preventing heat-induced chaperone mRNAs from condensing in the nucleus, ensuring their translation and chaperone production during heat shock.

Mechanochemical forces regulate the composition and fate of stalled nascent chains

The paper shows mechanochemical forces determine CAT tail composition, which controls nascent chain extrusion or release and ribosome recycling.

ReporterSeq reveals genome-wide determinants of proteasome expression

ReporterSeq identifies Trr1 and ribosomal proteins as novel regulators of the UPS master regulator Rpn4 in yeast under stress conditions.

Genome-wide, time-sensitive interrogation of the heat shock response under diverse stressors via ReporterSeq

The paper introduces ReporterSeq, a method to identify genetic regulators of the heat shock response across diverse stressors and timepoints in budding yeast.