Cole S. Sitron

The paper introduces the ZenoTOF 8600 system, which enhances proteomics by increasing ion flux and improving precursor identification and quantification in DIA mode.

Q-DOAS detects early protein aggregation events in real time using a proximity-quenching assay, providing quantitative data for studying neurodegenerative diseases.

This study shows that alpha-synuclein fibrils sequester and degrade ESCRT-III proteins, leading to endolysosomal damage and increased alpha-synuclein aggregation.

The paper shows mechanochemical forces determine CAT tail composition, which controls nascent chain extrusion or release and ribosome recycling.