Targeting the PD-1/PD-L1 pathway potentiates immunoediting and changes the dynamics of neutral evolution in a mouse model of colorectal cancer
Mirjana Efremova, Dietmar Rieder, Victoria Klepsch, Pornpimol Charoentong, Francesca Finotello, Hubert Hackl, Natascha Hermann‐Kleiter, Martin Löwer, Gottfried Baier, Anne Krogsdam, Zlatko Trajanoski
This study shows that neutral evolution dominates tumor shaping in a mouse CRC model, and PD-1/PD-L1 blockade enhances immunoediting and tumor homogeneity.
Nature Communications · Dec 27, 2017Peer-reviewedGenomics