GenomicsNature CommunicationsPeer-reviewed
Targeting the PD-1/PD-L1 pathway potentiates immunoediting and changes the dynamics of neutral evolution in a mouse model of colorectal cancer
Mirjana Efremova, Dietmar Rieder, Victoria Klepsch…·Zlatko Trajanoski
This study shows that neutral evolution dominates tumor shaping in a mouse CRC model, and PD-1/PD-L1 blockade enhances immunoediting and tumor homogeneity.
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