Anne Krogsdam

This study shows conventional therapy in CRC induces immunoediting and changes immune contexture, with AI identifying mucin deposits as a potential surrogate marker.

quanTIseq estimates absolute fractions of ten immune cell types from bulk RNA-seq; across TCGA, CXCL9/CXCR3 expression, not mutational load, tracks CD8+ T cell infiltration.

This study shows that neutral evolution dominates tumor shaping in a mouse CRC model, and PD-1/PD-L1 blockade enhances immunoediting and tumor homogeneity.