Mirjana Efremova

Thymic keratin76 shapes skin-specific central tolerance

This study shows that keratin76 in the thymus is crucial for central tolerance to skin and oral mucosa antigens, as its loss leads to autoimmune responses.

scMoMaT: Mosaic integration of single cell multi-omics data using matrix trifactorization

scMoMaT integrates single-cell multi-omics data under mosaic integration using matrix tri-factorization, uncovering modality-specific biomarkers for improved cell type annotation.

MultiMAP: Dimensionality Reduction and Integration of Multimodal Data

MultiMAP integrates multimodal data by reducing dimensionality and preserving structure, outperforming existing methods in various tasks.

Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome

This study uses single-cell RNA-sequencing to analyze fetal bone marrow development and identifies disruptions in hematopoiesis in Down syndrome.

CellPhoneDB v2.0: Inferring cell-cell communication from combined expression of multi-subunit receptor-ligand complexes

CellPhoneDB infers cell-cell communication by analyzing the combined expression of multi-subunit ligand-receptor complexes across cell types.

Decoding the development of the blood and immune systems during human fetal liver haematopoiesis

The paper uses single-cell transcriptomics to map hematopoiesis in human fetal liver, identifying cell differentiation trajectories and shifts in hematopoietic composition during development.

Single-cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment

This study uses single-cell RNA sequencing to analyze stromal cell changes in murine melanoma, identifying distinct CAF populations and their roles in immune suppression across tumor development.

Reconstructing the human first trimester fetal-maternal interface using single cell transcriptomics

The paper profiles single-cell transcriptomes from the human first trimester fetal-maternal interface, revealing cellular composition and interactions critical for placentation.

A novel innate lymphoid cell delineates childhood autoimmune arthritis

The paper identifies a novel synovial innate lymphoid cell (ILC) subtype associated with a specific type of childhood autoimmune arthritis, highlighting its role in inflammation and potential as a therapeutic target.

Targeting the PD-1/PD-L1 pathway potentiates immunoediting and changes the dynamics of neutral evolution in a mouse model of colorectal cancer

This study shows that neutral evolution dominates tumor shaping in a mouse CRC model, and PD-1/PD-L1 blockade enhances immunoediting and tumor homogeneity.

Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade

Immunogenomic profiling of 8243 TCGA samples across 20 solid cancers yields an immune atlas and a random-forest-derived immunophenoscore stratifying melanoma responders to checkpoint blockade.