Corbin Hopper

This paper develops a phage-mediated CRISPRi system for intercellular communication in bacterial consortia, enabling multicellular logic gates with up to 7 cells and 3 inputs.

The paper develops a synthetic communication system using phage M13 to study genetic exchange in E. coli and discovers an extracellular immunity factor that reduces infection rates by 70%.

The paper models molecular interaction networks as computational optimization problems, showing that their mLmH topology arises as an adaptation to computational intractability.