Highly Specific Enrichment of Rare Nucleic Acids using Thermus Thermophilus Argonaute with Applications in Cancer Diagnostics
Jinzhao Song, Jorrit W. Hegge, Michael G. Mauk, Junman Chen, Jacob Edward Till, Neha Bhagwat, Lotte T. Azink, Jing Yun Peng, Moen Sen, Jazmine J. Mays, Erica L. Carpenter, John van der OOST, Haim H. Bau
The paper introduces NAVIGATER, a method using TtAgo to enrich rare nucleic acid alleles, demonstrating 60-fold enrichment of KRAS G12D in pancreatic cancer blood samples.
Nucleic Acids Research · Dec 3, 2019Peer-reviewedBioengineering