Author

David Melamed

Columbia UniversityORCID 0000-0002-2102-1340Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:Drosophila· 5 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Daniel KalderoniD· 5 shared Amy R. ReileiniD· 4 shared Simon TavaréiD· 2 shared Aaron Choi· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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5 shared papersDevelopmental Biology

Daniel KalderonORCID

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5 papers

Recent·Most cited

Spatial regulation of Drosophila ovarian Follicle Stem Cell division rates and cell cycle transitions

David Melamed, Aaron Choi, Amy R. Reilein, Simon Tavaré, Daniel Kalderon

The paper measures division rates and cell cycle transitions in Drosophila ovarian Follicle Stem Cells, finding spatial differences and roles for JAK-STAT, Yorkie, and PI3 kinase signaling.

PLoS Genetics · Sep 25, 2023Peer-reviewedDevelopmental Biology

The number of Follicle Stem Cells in a Drosophila ovariole.

Daniel Kalderon, David Melamed, Amy R. Reilein

This paper critiques previous studies on Drosophila follicle stem cells, highlighting methodological issues in lineage analysis and emphasizing the need for comprehensive stem cell lineage studies.

bioRxiv · Oct 25, 2021 · PreprintDevelopmental Biology

Opposing Wnt and JAK-STAT signaling gradients define a stem cell domain by regulating spatially patterned cell division and differentiation at two borders

David Melamed, Daniel Kalderon

The paper shows that opposing Wnt and JAK-STAT signaling gradients regulate stem cell division and differentiation in Drosophila FSCs, defining a stem cell domain through spatially patterned behavior.

eLife · Nov 2, 2020Peer-reviewedDevelopmental Biology

Follicle Stem Cells (FSCs) in the Drosophila ovary; a critique of published studies defining the number, location and behavior of FSCs

Daniel Kalderon, David Melamed, Amy R. Reilein

The paper critiques previous studies on Drosophila ovary follicle stem cells (FSCs), supporting Reilein et al.'s findings of multiple FSCs per ovariole and challenging earlier claims of only two FSCs.

bioRxiv · Jun 25, 2020 · PreprintDevelopmental Biology

Division-independent differentiation mandates proliferative competition among stem cells

Amy R. Reilein, David Melamed, Simon Tavaré, Daniel Kalderon

The paper shows that faster-proliferating stem cell mutants outcompete others only when division and differentiation are independent, using Drosophila Follicle Stem Cells as a model.

Proceedings of the National Academy of Sciences · Mar 19, 2018Peer-reviewedDevelopmental Biology