Author

Aaron Choi

Massachusetts Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alan Y. L. JiangiD· 2 shared Alice E. StantoniD· 2 shared Claudia F. Lozano Cruz· 2 shared Colin Staab· 2 shared Emre Agbas· 2 shared Eulim Kang· 2 shared Li‐Huei TsaiiD· 2 shared Masayuki Nakano· 2 shared

Activity by Year

2017-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Alan Y. L. JiangORCID

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4 papers

Recent·Most cited

Inflammatory reprogramming of human brain endothelial cells compromises blood-brain barrier integrity in Alzheimer's disease

Rebecca L. Pinals, Rezaul Islam, Oisín King, Aaron Choi, Eulim Kang, Masayuki Nakano, Anjanet Tuyeras, Maeesha Tasnim Naomi, Arthur Ngo, Alan Y. L. Jiang, Nhat Truong, Emre Agbas, Claudia F. Lozano Cruz, Colin Staab, Tak Ko, , Li‐Huei Tsai

This study identifies an inflammation-driven gene module in brain endothelial cells that compromises BBB integrity in Alzheimer's disease and shows that an NF-κB inhibitor can reverse these effects.

bioRxiv · Sep 26, 2025 · PreprintNeuroscience

Vascular-Perfusable Human 3D Brain-on-Chip

Alice E. Stanton, Rebecca L. Pinals, Aaron Choi, Nhat Truong, Eulim Kang, Alan Y. L. Jiang, Claudia F. Lozano Cruz, Sydney Hawkins, Ryana Sarcar, Alexandra Volkova, Oisín King, Emre Agbas, Masayuki Nakano, Ching‐Chi Chiu, Adele Bubnys, , Li‐Huei Tsai

The paper develops a 3D Brain-Chip system using human iPSC-derived cells to model the BBB and study APOE4's role in Alzheimer's disease.

bioRxiv · Sep 18, 2025 · PreprintNeuroscience

Spatial regulation of Drosophila ovarian Follicle Stem Cell division rates and cell cycle transitions

David Melamed, Aaron Choi, Amy R. Reilein, Simon Tavaré, Daniel Kalderon

The paper measures division rates and cell cycle transitions in Drosophila ovarian Follicle Stem Cells, finding spatial differences and roles for JAK-STAT, Yorkie, and PI3 kinase signaling.

PLoS Genetics · Sep 25, 2023Peer-reviewedDevelopmental Biology

Edge Detection of Cryptic Lamellipodia Assisted by Deep Learning

Chuangqi Wang, Shawn Kang, Eunice Kim, Xitong Zhang, Hee June Choi, Aaron Choi, Kwonmoo Lee

This paper uses deep learning to detect cryptic lamellipodia edges in fluorescence time-lapse movies of collective cell migration, improving accuracy over conventional methods.

bioRxiv · Sep 13, 2017 · PreprintBioinformatics