Daniel Kalderon

Regulation of somatic stem cell precursor fates and proliferation during Drosophila melanogaster pupal ovary development resembles the signaling framework for adult stem cell behavior

The paper investigates how signaling pathways regulate stem cell precursor fates and proliferation during Drosophila pupal ovary development, finding similarities to adult stem cell behavior.

Physiological analysis of the mechanism of Ci transcription factor activation through multiple Fused phosphorylation sites in Hedgehog signal transduction

The paper investigates how phosphorylation sites on Ci regulate its activation in Drosophila through interactions with Fu kinase and Su(fu), revealing new insights into Ci conformation and activation mechanisms.

Spatial regulation of Drosophila ovarian Follicle Stem Cell division rates and cell cycle transitions

The paper measures division rates and cell cycle transitions in Drosophila ovarian Follicle Stem Cells, finding spatial differences and roles for JAK-STAT, Yorkie, and PI3 kinase signaling.

Determination of expression profiles for Drosophila ovarian Follicle Stem Cells (FSCs) using single-cell RNA sequencing

The paper uses single-cell RNA sequencing to determine expression profiles of Drosophila ovarian Follicle Stem Cells and neighboring cell types, revealing AP progression and candidate genes involved in signaling pathways.

The number of Follicle Stem Cells in a Drosophila ovariole.

This paper critiques previous studies on Drosophila follicle stem cells, highlighting methodological issues in lineage analysis and emphasizing the need for comprehensive stem cell lineage studies.

Adult Stem Cells and Niche Cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development

The paper shows that adult stem cells and niche cells in Drosophila develop from common precursors during pupal stages, with progeny including multiple cell types.

Opposing Wnt and JAK-STAT signaling gradients define a stem cell domain by regulating spatially patterned cell division and differentiation at two borders

The paper shows that opposing Wnt and JAK-STAT signaling gradients regulate stem cell division and differentiation in Drosophila FSCs, defining a stem cell domain through spatially patterned behavior.

Drosophila Hedgehog can act as a morphogen in the absence of regulated Ci processing

This study shows that Drosophila Hedgehog can function as a morphogen without requiring regulated Ci processing, as Ci variants resistant to processing support normal gene activation and wing development.

Follicle Stem Cells (FSCs) in the Drosophila ovary; a critique of published studies defining the number, location and behavior of FSCs

The paper critiques previous studies on Drosophila ovary follicle stem cells (FSCs), supporting Reilein et al.'s findings of multiple FSCs per ovariole and challenging earlier claims of only two FSCs.

Division-independent differentiation mandates proliferative competition among stem cells

The paper shows that faster-proliferating stem cell mutants outcompete others only when division and differentiation are independent, using Drosophila Follicle Stem Cells as a model.