Myeloid-specific TFAM deficiency drives mitochondrial DNA stress and exacerbates allergic airway inflammation
Jackie Nguyen, Courtney Van, Manjula Karpurapu, Jiyoung Kim, Tae Jin Lee, Ji Young Yoo, Navjotsingh Pabla, John William Christman, Sangwoon Chung
This study shows that myeloid-specific TFAM deficiency causes mitochondrial DNA stress and worsens allergic airway inflammation in mice.
bioRxiv · May 27, 2025 · PreprintImmunology