Mineralocorticoid and glucocorticoid receptor interaction drives TGFB1-induced triple-negative breast cancer progression to metastasis
Sai Harshita Posani, Caroline H. Diep, Raisa I. Krutilina, Hilaire Smith, Tiffany Nicole Seagroves, John Blenis, Carol Ann Lange
This study shows that mineralocorticoid receptor (MR) and phosphorylated glucocorticoid receptor (p-GR) interaction promotes triple-negative breast cancer (TNBC) metastasis through migratory, stemness, and fibrotic mechanisms.
bioRxiv · Nov 3, 2025 · PreprintCancer Biology