Author

Sai Harshita Posani

University of MinnesotaORCID 0009-0002-6987-8375Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Carol Ann LangeiD· 2 shared Amy R. DwyeriD· 1 shared Carlos Jesus Perez KerkvlietiD· 1 shared Caroline H. DiepiD· 1 shared Ellie Piepgras· 1 shared Geoffrey L. GreeneiD· 1 shared Hilaire SmithiD· 1 shared John BlenisiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Carol Ann LangeORCID

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2 papers

Recent·Most cited

Progesterone receptors drive advanced breast cancer phenotypes including circulating tumor- and stem-like cell expansion in the context of ESR1 mutation

Thu Ha Truong, Noelle E. Gillis, Amy R. Dwyer, Rosemary J. Huggins, Kyla M. Hagen, Sai Harshita Posani, Nuri A. Temiz, Carlos Jesus Perez Kerkvliet, Ellie Piepgras, Julie Hanson Ostrander, Geoffrey L. Greene, Carol Ann Lange

This study shows that progesterone receptors (PR) interact with mutant ESR1 variants in ER+ breast cancer, driving CSC expansion and UPR activation, which can be targeted therapeutically.

npj Breast Cancer · Apr 7, 2026Peer-reviewedCancer Biology

Mineralocorticoid and glucocorticoid receptor interaction drives TGFB1-induced triple-negative breast cancer progression to metastasis

Sai Harshita Posani, Caroline H. Diep, Raisa I. Krutilina, Hilaire Smith, Tiffany Nicole Seagroves, John Blenis, Carol Ann Lange

This study shows that mineralocorticoid receptor (MR) and phosphorylated glucocorticoid receptor (p-GR) interaction promotes triple-negative breast cancer (TNBC) metastasis through migratory, stemness, and fibrotic mechanisms.

bioRxiv · Nov 3, 2025 · PreprintCancer Biology