Carol Ann Lange

This study shows that progesterone receptors (PR) interact with mutant ESR1 variants in ER+ breast cancer, driving CSC expansion and UPR activation, which can be targeted therapeutically.

This study shows that BRCA1 depletion in ovarian cancer cells enhances progestin-induced cytoskeletal changes and migration through altered PR phosphorylation and Rho-GTPase pathways.

This study shows that mineralocorticoid receptor (MR) and phosphorylated glucocorticoid receptor (p-GR) interaction promotes triple-negative breast cancer (TNBC) metastasis through migratory, stemness, and fibrotic mechanisms.

This study shows that circulating cancer-associated fibroblasts (cCAFs) enhance breast cancer cell extravasation by promoting urokinase plasminogen activator (uPA) expression, facilitating metastasis.

The paper investigates how PR-A and PR-B isoforms regulate divergent gene expression and phenotypes in breast cancer cells, showing PR-A is linked to poor clinical outcomes.