Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models
Electra Brunialti, Alessandro Maria Villa, Éva M. Szegő, Pietro La Vitola, Denise Drago, Radmila Pavlović, Laura Fontana, Doga Tuna, Alessia Panzeri, Clara Meda, Christin Weissleder, Ornella Rondinone, Mattia Pitasi, Monica Rosa Miozzo, Michela Deleidi, , Paolo Ciana
This study shows that GCase deficiency in microglia leads to metabolic changes and ATP depletion, impairing their neuroprotective functions and increasing neuronal vulnerability in Parkinson's disease.
Journal of Neuroinflammation · Nov 25, 2025Peer-reviewedNeuroscience