Michela Deleidi

Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture

This paper develops a method to generate human midbrain organoids enriched in SNpc-like dopaminergic neurons using WNT modulation and bioreactor culture, showing improved functionality and vulnerability to Parkinson's disease pathology.

An N-acylphosphatidylethanolamine-LRRK2 axis controls lysosomal homeostasis in Parkinson s disease

This study identifies NAPEs as regulators of LRRK2 and lysosomal function in Parkinson's disease, showing that boosting NAPEs reduces LRRK2 activity and clears alpha-synuclein aggregates.

Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models

This study shows that GCase deficiency in microglia leads to metabolic changes and ATP depletion, impairing their neuroprotective functions and increasing neuronal vulnerability in Parkinson's disease.

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC- Derived Microglia and Modulates Glial-Neuronal Crosstalk

This study investigates how C9orf72 repeat expansion affects metabolism in human iPSC-derived microglia and its impact on glial-neuronal interactions in ALS.

Astrocytic Ceruloplasmin Deficiency Triggers Iron Toxicity and Neurodegeneration in a LRRK2 Parkinson's Tri-Culture Model

This study identifies ceruloplasmin deficiency in mutant astrocytes as a driver of iron toxicity and neurodegeneration in a Parkinson's tri-culture model.

The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence

This study shows that mitochondrial stress in human microglia disrupts communication with neurons and promotes senescence, contributing to neurodegenerative processes.

LRRK2-G2019S SYNERGIZES WITH AGEING AND LOW-GRADE INFLAMMATION TO PROMOTE GUT AND PERIPHERAL IMMUNE CELL ACTIVATION THAT PRECEDE NIGROSTRIATAL DEGENERATION

This study shows that LRRK2 G2019S mutation interacts with low-grade inflammation and aging to promote gut and peripheral immune activation before nigrostriatal degeneration in mice.

The activities of LRRK2 and GCase are positively correlated in clinical biospecimens and experimental models of Parkinson's disease

The paper investigates the relationship between LRRK2 and GCase activities in Parkinson's disease models and biospecimens, finding a positive correlation.

mTOR inhibition via Rapamycin treatment partially reverts the deficit in energy metabolism caused by FH loss in RPE cells

This study shows that mTOR inhibition with rapamycin partially rescues metabolic defects in RPE cells caused by CFH loss, suggesting a link between intracellular FH and the ubiquitin-proteasomal pathway.

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids

This study shows that PITRM1 deficiency in human cerebral organoids leads to Alzheimer's-like pathology, including protein aggregates and tau pathology, while 2D cultures do not show these features.

Interferon-γ signaling synergizes with LRRK2 in human neurons and microglia

This study shows that IFN-γ and LRRK2 synergize in human neurons and microglia, leading to defects in neurite elongation and microglial activation.