Differential role of phosphorylation in glucagon family receptor signaling revealed by mass spectrometry
Ian M. Lamb, Alex D. White, Francis S. Willard, Michael J. Chalmers, Junpeng Xiao
This study identifies phosphorylated C-tail residues in glucagon family GPCRs and shows their differential effects on βarr recruitment and cAMP production across GLP-1R, GCGR, and GIPR.
Journal of Proteome Research · Jun 12, 2025Peer-reviewedPharmacology & Toxicology