The paper identifies phospholipidosis as a common artifact in antiviral drug repurposing and introduces a microplate-based assay to detect it, finding that 65% of tested drugs induce it.

bioRxiv · Nov 20, 2025 · PreprintCell Biology

Differential role of phosphorylation in glucagon family receptor signaling revealed by mass spectrometry

Ian M. Lamb, Alex D. White, Francis S. Willard, Michael J. Chalmers, Junpeng Xiao

This study identifies phosphorylated C-tail residues in glucagon family GPCRs and shows their differential effects on βarr recruitment and cAMP production across GLP-1R, GCGR, and GIPR.

Journal of Proteome Research · Jun 12, 2025Peer-reviewedPharmacology & Toxicology

Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH)

Sesh A. Sundararaman, Justin J. Miller, Ellora C. Daley, Kelsey O’Brien, Paulina Kasak, Abigail M. Daniels, Rachel L. Edwards, Kenneth M. Heidel, Darean A. Bague, Madeleine A. Wilson, Andrew J. Koelper, Elexi C. Kourtoglou, Alex D. White, Sloan A. August, Georgia A. Apple, , Audrey R. Odom John

The paper identifies acylpeptide hydrolase (APEH) from red blood cells as an enzyme imported by malaria parasites that activates lipophilic ester prodrugs, offering a new strategy to overcome drug resistance.

Proceedings of the National Academy of Sciences · Mar 4, 2025Peer-reviewedMicrobiology