Author

Disha M. Soni

Indiana University Indianapolis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Adrian L. OblakiD· 4 shared Bruce T. LambiD· 3 shared Emily R. Mason· 3 shared Shaoyou Chu· 3 shared Timothy I. RichardsoniD· 3 shared Bridget M Perkins· 2 shared Gareth R. HowelliD· 2 shared Gregory W. CarteriD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersNeuroscience

Adrian L. OblakORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models

Cynthia D. Jesudason, Claudia Rangel‐Barajas, Colin J Beach, Daniel E. Beck, Isaac Caballero-Floran, Brent Clayton, Lais Da Silva, Juliane C David, Suzanne Doolen, Alexandra N. Faulkner, Adam K. Hamdani, Hasi Huhe, Kevin Huynh, Ryan D. Imhoff, June Javens‐Wolfe, , Timothy I. Richardson

This study identifies SHIP1 ligands with brain exposure and in vivo activity in Alzheimer's models, showing target engagement and reduced neuroinflammation.

Journal of Medicinal Chemistry · Apr 30, 2026Peer-reviewedPharmacology & Toxicology

SHIP1 modulation and proteome characterization of microglia

Erpan Ahat, Zanyu Shi, Shaoyou Chu, Hai Hoang Bui, Emily R. Mason, Disha M. Soni, Kenneth D. W. Roth, Michael J. Chalmers, Adrian L. Oblak, Jie Zhang, Jesus A. Gutierrez, Timothy I. Richardson

This study examines the proteomic and transcriptomic effects of SHIP1 modulation in microglia, revealing significant proteomic changes in SHIP1 homozygous knockout and differences between BV2 and HMC3 cell lines.

Journal of Proteomics · May 20, 2024Peer-reviewedNeuroscience

In vivo validation of late-onset Alzheimer's disease genetic risk factors

Michael Sasner, Christoph Preuß, Ravi S. Pandey, Asli Uyar, Dylan T. Garceau, Kevin P. Kotredes, Harriet M. Williams, Adrian L. Oblak, Peter Bor‐Chian Lin, Bridget M Perkins, Disha M. Soni, Cindy Ingraham, Audrey Lee‐Gosselin, Bruce T. Lamb, Gareth R. Howell, Gregory W. Carter

The paper functionally validates 11 genetic risk variants for late-onset Alzheimer's disease using a mouse model and compares transcriptomic effects to human cohorts.

Alzheimer s & Dementia · Apr 30, 2024Peer-reviewedNeuroscience

Plcg2M28L interacts with high fat-high sugar diet to accelerate Alzheimers disease-relevant phenotypes in mice

Adrian L. Oblak, Kevin P. Kotredes, Ravi S. Pandey, Alaina M. Reagan, Cynthia M. Ingraham, Bridget M Perkins, Christopher Lloyd, Deborah Baker, Peter Bor‐Chian Lin, Disha M. Soni, Andy Po‐Yi Tsai, Scott A. Persohn, Amanda A. Bedwell, Kierra Eldridge, Rachael Speedy, , Gareth R. Howell

This study shows that a high fat-high sugar diet interacts with the Plcg2M28L genetic variant to accelerate Alzheimer's disease-like phenotypes in mice.

Frontiers in Aging Neuroscience · Jun 24, 2022Peer-reviewedNeuroscience

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

Frances Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva Krishna Reddy Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri Kireev, Emily R. Mason, Charles Travis Moerk, Felix O. Nwogbo, Kenneth H. Pearce, , Alison Donnelly Axtman

The paper compiles an annotated set of 171 small molecule modulators targeting 98 novel AD therapeutic proteins, serving as chemical tools for hypothesis validation.

Alzheimer s & Dementia Translational Research & Clinical Interventions · Jan 1, 2022Peer-reviewedNeuroscience