Reconstitution of glycan-driven MHC I recycling reveals calreticulin as mediator between TAPBPR and tapasin
Tim Julius Heinke, Amin Fahim, Niko Popovic, Tobias Rath, Ines Katharina Müller, Nina Morgner, Simon Trowitzsch, Robert Tampé
The paper reveals calreticulin mediates glycan-dependent transfer of MHC I from TAPBPR to tapasin, essential for MHC I recycling and quality control.
The EMBO Journal · Aug 17, 2026Peer-reviewedImmunology