Arslan A. Zaidi

Proteogenomic origins of disease in British South Asians

This study integrates genetic variation with plasma protein measurements in South Asians to identify pQTLs and build a proteogenomic disease network for understudied populations.

Beyond copy number: The regulatory architecture of mitochondrial DNA gene expression

The paper investigates the relationship between mtDNA copy number and gene expression, finding they are largely decoupled and that mtDNA accessibility, not copy number, better explains expression variation.

Interpreting SNP heritability in admixed populations

The paper analyzes how SNP heritability estimates are affected by admixture and directional LD, showing biases in random-effect estimators and implications for GWAS and polygenic prediction.

The multi-scale complexity of human genetic variation beyond continental groups

The paper introduces a network-based method to analyze human genetic variation beyond continental groups, revealing complex relationships and challenging traditional clustering approaches.

The genetic and phenotypic correlates of mtDNA copy number in a multi-ancestry cohort

This study investigates mtDNA copy number (mtCN) in a diverse cohort, finding ancestry-specific genetic and phenotypic associations and highlighting the impact of blood cell composition on results.

Long runs of homozygosity are correlated with marriage preferences across global population samples

The paper shows that cousin marriage preferences increase long runs of homozygosity (ROH) in global populations by 1.5 times, but marriage practices explain only a small portion of ROH variation.

High-throughput phenotyping methods for quantifying hair fiber morphology

The paper introduces a high-throughput method for imaging and analyzing scalp hair morphology and validates a Python package for processing and measuring hair images.

Demographic history impacts stratification in polygenic scores

This study shows that demographic history affects population stratification in polygenic scores, with recent structure being hard to correct using standard methods.

Robust Genome-Wide Ancestry Inference for Heterogeneous Datasets and Ancestry Facial Imaging based on the 1000 Genomes Project

This paper introduces SUGIBS, a robust genome-wide ancestry inference method, and applies it to predict ancestry faces using the 1000 Genomes Project and facial imaging data.

Mito-nuclear effects uncovered in admixed populations

The paper investigates mito-nuclear incompatibility in admixed populations, finding that mtDNA copy number decreases with increasing discordance between nuclear and mitochondrial ancestry.

A population phylogenetic view of mitochondrial heteroplasmy

The paper develops a population-genetic framework to model mitochondrial heteroplasmy inheritance and applies it to infer genetic drift and mutation rates during human development.